2018.12.1. Combining both experiments and simulations, we showed that the early aggregation of full-length hIAPP features the accumulation of helix-rich oligomers, among which the nucleation of beta-rich structures and beta-barrels takes place. The work first authored by Yunxiang is now published in BBA - Molecular Basis of Disease.
2018.10.20. Our joint work with Monash University, Tongji University, and Qingdao University on inhibiting hIAPP aggregation and toxicity with Graphene Quantum Dots is accepted for publication in Nanoscale. Congratulations to Dr. Yunxiang Sun!
2018.10.1 Our combined computational and experimental work about the effects of Chiral Silica Nanoribbons on hIAPP aggregation is in press with Small. Congratulations to Dr. Yunxiang Sun and the collaboration team!
2018.9.15. Our joint work with Dr. Hugo Sannabria and Dr. Mark Bowen on identifying the weakly populated conformational states of PDZ1-2 of PSD-95 are published in Nature Comm. Congratulations to Bo!
2018.5.10. Our joint work with ARC Centre of Excellence in Convergent Bio-Nano Science and Technology in Australia and University of Warwick in UK on serum protein binding with hIAPP amyloid fibrils - i.e., the formation of amyloid corona - is published in ACS Nano. Congratulations to Yanting!
2018.1.29. Our work on uncovering the molecular mechanism of the cross-talk between Alzheimer's disease and type-2 diabetes is now in press with ACS Chemical Neuroscience. Congratulations to Xinwei, Yang Ye and Yunxiang!
2017.10.17. Our joint work with Monash University (Australia) entitled "Star Polymers Reduce IAPP Toxicity via Accelerated Amyloid Aggregation" is now accepted for publication in Biomacromolecules. Congratulations to Xinwei and Bo!
2017.10.1. Yunxiang's paper on the Oligomerization and Fibrillization dynamics of peptides is accepted for publication in PCCP, where the aggregation free energy landscape is directly visualized!
Congratulations to Yunxiang!
2017.7.25. Our review entitled "Modulating protein amyloid aggregation with nanomaterials" is now accepted for publication in ES Nano. Congratulations to Bo and Yunxiang!
2017.7.19. Our work on the endogenous inhibition of IAPP aggregation in pancreatic beta-cells, first authored by Xinwei, is now accepted for publication in Chem. Comm. The work is also featured as the front cover article. Congratulations to Xinwei!
2017.6.26. Our review paper "NanoEHS beyond toxicity – focusing on biocorona" has been selected as the front cover article by Environmental Science: Nano.
2017.5.15. Dr. Ding receives the Outstanding Young Researcher Award from College of Science, Clemson.
2017.2.24. Bo Wang is awarded outstanding graduate researcher by both the department and the new College of Science. Congratulations to Bo!
2016.9.23. Our paper "Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding" first authored by Bo and co-authored by Xinwei is accepted for publication in Polymer Chemistry. The work suggests that brushed phosphorylcholine polymer is a better alternative to PEG as the grafting agent of nanoparticles to achieve anti-fouling properties.
2016.9.1. Bo Wang is awarded a career development supplement grant from NSF. Congratulations to Bo!
2016.8.31. Congratulations to the lab for being awarded the NIGMS MIRA award! The project is entitled "Inhibition of Human Islet Amyloid Polypeptide Aggregation", which will allow us to uncover the aggregation mechanism of IAPP in type-2 diabetes and search for novel anti-amyloid approaches from three directions, including 1) the endogenous inhibition of IAPP aggregation in healthy individuals, 2) the inhibition of IAPP aggregation by small molecules, and 3) de novo designed nanomaterials with anti-aggregation properties.
2016.8.26. The positions have been filled! -- Our lab has an on-going opening for one or two postdoctoral fellows. The research project is supported by NIH to investigate amyloid aggregation related to type-2 diabetes and search for novel anti-amyloid therapeutic approaches.
2016.2.25. Our latest Small journal paper is highlighted in the current issue of Pancreatic Cell News. The work is the result of an international collaboration between Clemson University, University of Melbourne, St Vincent's Institute of Medical Research, and University of Michigan.
2016.2.16. Dr. Ding is selected for an NSF CAREER award - "Multiscale Study of the Structure and Dynamics of Nanoparticle-Protein Coronae".